Endocrine Abstracts

Screening is a process of identifying apparently healthy people at increased risk of a disease or condition. They can then be offered appropriate treatment to reduce the risk arising from the disease or condition.Thyroid autoimmunity (TAI), defined by the presence of antibodies against thyroperoxidase and thyroglobulin, have been associated with adverse pregnancy outcomes, infertility, and impaired child neurodevelopment. However, associations do not nec...

The 22q11.2 deletion syndrome is a clinical syndrome caused by a hemizygous deletion in the chromosome 22q11.2. Clinical findings include cardiac defects, characteristic facial features, thymic hypoplasia, cleft palate, hypoparathyroidism, learning difficulties and psychiatric disorders. The importance of chromosome 22 relies on small number of genes located in the long (Q) arm participating in the development of the body plan, including the pharyngeal arches during the embryo...

Background: Ovarian mucinous cystadenomas are classically considered as ‘non-functional’ tumors. Cystadenomas are among the most common benign ovarian neoplasms. Compared with serous cystadenomas, mucinous cystadenomas occur less frequently, are more often unilateral and can attain an enormous size. Most of these tumors are asymptomatic and found incidentally on pelvic examination or with ultrasound. We present an unusual case of a mucinous cystadenoma presenting w...

Autoimmune Addison’s disease (AAD) is widely believed to be associated with total loss of endogenous mineralocorticoid and glucocorticoid production and secretion, due to cell-mediated immune destruction. Therefore, patients with AAD are prescribed lifelong mineralocorticoid and glucocorticoid replacement therapy. We present a case of a 69 year old women known with polyglandular autoimmune disease type 2 (hypothyroidism, Addison’s disease and premature ovarian fail...

A 64-year old man presented to our endocrinology clinic with progressive lumbar pain that had developed two months earlier. He had undergone bilateral adrenalectomy for Cushing disease and two years later transsphenoidal resection for Nelson tumor. On physical examination, the patient had remarkable hyperpigmentation due to ACTH hypersecretion periorbital, peri-auricular and in the lower-neck region. These findings were clearly evident in his case due to the extensive facial v...

Background: Currently, physicians remain uncertain whether to screen and/or treat subclinical thyroid disease. Many observational studies, including cross-sectional, case–control, and prospective cohort studies, have reported on the association between subclinical thyroid disease and an ‘outcome of interest’. All cause mortality, coronary heart disease, fracture risk, and pregnancy outcome may drive the decision to screen or treat subclinical thyroid disease.</p...

Background: In Belgium, a land with borderline iodine intake, the prevalence of goiter is 6 to 40%. This raises the question of an economically affordable treatment with few side effects. In euthyroid goiters, the effect of radioiodine on volume reduction is debated. Most data were described last century and do not take into account recent thyroid hormone measurements, newer ultrasonography techniques and changes in iodine supplementation. Doses administered in the past and el...

Introduction: Diagnosis and treatment of neurosarcoidosis (NS) can be challenging. We describe an unsual presentation of an isolated NS in a 21 year old adult, initially presenting with central diabetes insipidus (DI) associated with a stalk thickening at the age of 14.Case description: A 21 year old patient was first seen at the department of endocrinology after a 9 years follow-up for panhypopituitarism. He presented at the age of 14 years at the pedia...

Background: Thyroid nodules are a common finding in clinical practice. Among classic risk factors for thyroid cancer, thyroid scintigraphy has traditionally been attributed prognostic value, with cold nodules implying greater risk. However, research supporting this assumption is of considerable age and possibly influenced by selection bias. In this study, we aimed to calculate the risk of malignancy in cold and hot nodules.Material and Methods: All thyro...

Introduction: The first-line imaging modalities to locate adenomas preoperatively in primary hyperparathyroidism (PHPT) are ultrasonography (US) and subtraction scintigraphy (SuSc). When these contradict each other or are inconclusive an [11C]-methionine PET/CT (MET-PET/CT) or a 4-dimensional computed tomography (4D-CT) can be performed.Objectives: The aim of this retrospective study was to evaluate the value of MET-PET/CT in the preoperative localizatio...